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Neuroblastic tumor

MedGen UID:: 233228
•Concept ID:: C1334953
•: Neoplastic Process

Synonym:	Neuroblastic tumour

HPO:	HP:0004376
Monarch Initiative:	MONDO:0006316

Definition

A family of tumors arising in the embryonal remnants of the sympathetic nervous system, which includes neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeuroblastic tumor

Pathological process
- Disease
  - Neoplasm
    - Malignant neoplastic disease
      - Malignant neoplasm of nervous system
        Malignant neoplasm of the central nervous system
        Neuroblastic tumor
        Ganglioneuroblastoma
        Central Nervous System Ganglioneuroblastoma
        Childhood Central Nervous System Ganglioneuroblastoma
        Childhood Ganglioneuroblastoma
        Childhood Ganglioneuroblastoma, Intermixed
        Childhood Ganglioneuroblastoma, Nodular
        Intermixed schwannian stroma-rich ganglioneuroblastoma
        Adrenal Gland Ganglioneuroblastoma, Intermixed
        Nodular ganglioneuroblastoma
        Adrenal Gland Ganglioneuroblastoma, Nodular
        Schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma
        Stroma-dominant and stroma-poor composite ganglioneuroblastoma
        Peripheral ganglioneuroblastoma
        Adrenal gland ganglioneuroblastoma
        Mediastinum ganglioneuroblastoma
        Recurrent Ganglioneuroblastoma
        Refractory Ganglioneuroblastoma
        Neuroblastoma
        Cerebral neuroblastoma
        Childhood Central Nervous System Neuroblastoma
        Childhood Neuroblastoma
        Congenital neuroblastoma
        Differentiating neuroblastoma
        Esthesioneuroblastoma
        Kadish Stage A Olfactory Neuroblastoma
        Kadish Stage B Olfactory Neuroblastoma
        Kadish Stage C Olfactory Neuroblastoma
        Nasal cavity olfactory neuroblastoma
        Recurrent Olfactory Neuroblastoma
        Sinonasal Olfactory Neuroblastoma
        Extracranial neuroblastoma
        Peripheral Neuroblastoma
        Spinal cord neuroblastoma
        Hereditary Neuroblastoma
        High Risk Neuroblastoma
        Localized neuroblastoma
        Metastatic Neuroblastoma
        Neuroblastoma, susceptibility to, 1
        Neuroblastoma, susceptibility to, 2
        Neuroblastoma, susceptibility to, 3
        Poorly Differentiated Neuroblastoma
        Recurrent Neuroblastoma
        Refractory Neuroblastoma
        Regional Neuroblastoma
        Resectable Neuroblastoma
        Localized Resectable Neuroblastoma
        Retinoblastoma
        bilateral retinoblastoma
        Differentiated Retinoblastoma
        Diffuse Retinoblastoma
        Extraocular retinoblastoma
        Hereditary retinoblastoma
        Intraocular retinoblastoma
        Non-hereditary retinoblastoma
        Recurrent Retinoblastoma
        Retinoblastoma by AJCC v8 Stage
        Sporadic Retinoblastoma
        Trilateral retinoblastoma
        Undifferentiated Retinoblastoma
        Unilateral retinoblastoma
        Sellar Neuroblastoma
        Stage 1 Neuroblastoma
        Stage 2 Neuroblastoma
        Stage 2A Neuroblastoma
        Stage 2B Neuroblastoma
        Stage 3 Neuroblastoma
        Stage 4 Neuroblastoma
        Stage 4S Neuroblastoma
        Undifferentiated Neuroblastoma
        Unresectable Neuroblastoma
        Localized Unresectable Neuroblastoma

Professional guidelines

PubMed

DO THE RADIOLOGICAL CRITERIA WITH THE USE OF RISK FACTORS IMPACT THE FORECASTING OF ABDOMINAL NEUROBLASTIC TUMOR RESECTION IN CHILDREN?

Penazzi ACS, Tostes VS, Duarte AAB, Lederman HM, Caran EMM, Abib SCV
Arq Bras Cir Dig 2017 Apr-Jun;30(2):88-92. doi: 10.1590/0102-6720201700020003. PMID: 29257841 Free PMC Article

Early Detection and Treatment of Neuroblastic Tumor with Opsoclonus-Myoclonus Syndrome Improve Neurological Outcome: A Review of Five Cases at a Single Institution in Japan.

Takama Y, Yoneda A, Nakamura T, Nakaoka T, Higashio A, Santo K, Kuki I, Kawawaki H, Tomiwa K, Hara J
Eur J Pediatr Surg 2016 Feb;26(1):54-9. Epub 2015 Sep 26 doi: 10.1055/s-0035-1564714. PMID: 26409265

Outcome prediction and risk assessment by quantitative pyrosequencing methylation analysis of the SFN gene in advanced stage, high-risk, neuroblastic tumor patients.

Banelli B, Bonassi S, Casciano I, Mazzocco K, Di Vinci A, Scaruffi P, Brigati C, Allemanni G, Borzì L, Tonini GP, Romani M
Int J Cancer 2010 Feb 1;126(3):656-68. doi: 10.1002/ijc.24768. PMID: 19626586

See all (4)

Recent clinical studies

Etiology

Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies.

Raitio A, Losty PD
J Pediatr Surg 2024 Aug;59(8):1611-1614. Epub 2024 Feb 26 doi: 10.1016/j.jpedsurg.2024.02.018. PMID: 38490882

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.

Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847

Biomarkers in Neuroblastoma: An Insight into Their Potential Diagnostic and Prognostic Utilities.

Shawraba F, Hammoud H, Mrad Y, Saker Z, Fares Y, Harati H, Bahmad HF, Nabha S
Curr Treat Options Oncol 2021 Sep 27;22(11):102. doi: 10.1007/s11864-021-00898-1. PMID: 34580780

Peripheral neck nerve tumor: A 73-case study and literature review.

Boumaza K, Michel G, Salaud C, Bossard C, Espitalier F, Malard O
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Nov;136(6):455-460. Epub 2019 Sep 16 doi: 10.1016/j.anorl.2019.09.005. PMID: 31537489

HMGA molecules in neuroblastic tumors.

Cerignoli F, Ambrosi C, Mellone M, Assimi I, di Marcotullio L, Gulino A, Giannini G
Ann N Y Acad Sci 2004 Dec;1028:122-32. doi: 10.1196/annals.1322.013. PMID: 15650238

See all (45)

Diagnosis

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.

Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847

Peripheral neck nerve tumor: A 73-case study and literature review.

Boumaza K, Michel G, Salaud C, Bossard C, Espitalier F, Malard O
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Nov;136(6):455-460. Epub 2019 Sep 16 doi: 10.1016/j.anorl.2019.09.005. PMID: 31537489

Trilateral retinoblastoma.

Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Retinoblastoma.

Melamud A, Palekar R, Singh A
Am Fam Physician 2006 Mar 15;73(6):1039-44. PMID: 16570739

Neuroblastoma-like neurilemoma.

Goldblum JR, Beals TF, Weiss SW
Am J Surg Pathol 1994 Mar;18(3):266-73. doi: 10.1097/00000478-199403000-00006. PMID: 8116794

See all (66)

Therapy

Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies.

Raitio A, Losty PD
J Pediatr Surg 2024 Aug;59(8):1611-1614. Epub 2024 Feb 26 doi: 10.1016/j.jpedsurg.2024.02.018. PMID: 38490882

Thyroid function after diagnostic (123)I-metaiodobenzylguanidine in children with neuroblastic tumors.

Clement SC, Tytgat GAM, van Trotsenburg ASP, Kremer LCM, van Santen HM
Ann Nucl Med 2022 Jun;36(6):579-585. Epub 2022 May 2 doi: 10.1007/s12149-022-01743-7. PMID: 35499668 Free PMC Article

Biomarkers in Neuroblastoma: An Insight into Their Potential Diagnostic and Prognostic Utilities.

Shawraba F, Hammoud H, Mrad Y, Saker Z, Fares Y, Harati H, Bahmad HF, Nabha S
Curr Treat Options Oncol 2021 Sep 27;22(11):102. doi: 10.1007/s11864-021-00898-1. PMID: 34580780

Distribution of segmental chromosomal alterations in neuroblastoma.

Juan Ribelles A, Gargallo P, Ferriol C, Segura V, Yáñez Y, Juan B, Cañada AJ, Font de Mora J, Cañete A, Castel V
Clin Transl Oncol 2021 Jun;23(6):1096-1104. Epub 2020 Sep 18 doi: 10.1007/s12094-020-02497-2. PMID: 32948984

Trilateral retinoblastoma.

Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

See all (16)

Prognosis

Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies.

Raitio A, Losty PD
J Pediatr Surg 2024 Aug;59(8):1611-1614. Epub 2024 Feb 26 doi: 10.1016/j.jpedsurg.2024.02.018. PMID: 38490882

Biomarkers in Neuroblastoma: An Insight into Their Potential Diagnostic and Prognostic Utilities.

Shawraba F, Hammoud H, Mrad Y, Saker Z, Fares Y, Harati H, Bahmad HF, Nabha S
Curr Treat Options Oncol 2021 Sep 27;22(11):102. doi: 10.1007/s11864-021-00898-1. PMID: 34580780

Peripheral neck nerve tumor: A 73-case study and literature review.

Boumaza K, Michel G, Salaud C, Bossard C, Espitalier F, Malard O
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Nov;136(6):455-460. Epub 2019 Sep 16 doi: 10.1016/j.anorl.2019.09.005. PMID: 31537489

Trilateral retinoblastoma.

Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Retinoblastoma.

Melamud A, Palekar R, Singh A
Am Fam Physician 2006 Mar 15;73(6):1039-44. PMID: 16570739

See all (54)

Clinical prediction guides

Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies.

Raitio A, Losty PD
J Pediatr Surg 2024 Aug;59(8):1611-1614. Epub 2024 Feb 26 doi: 10.1016/j.jpedsurg.2024.02.018. PMID: 38490882

Biomarkers in Neuroblastoma: An Insight into Their Potential Diagnostic and Prognostic Utilities.

Shawraba F, Hammoud H, Mrad Y, Saker Z, Fares Y, Harati H, Bahmad HF, Nabha S
Curr Treat Options Oncol 2021 Sep 27;22(11):102. doi: 10.1007/s11864-021-00898-1. PMID: 34580780

Distribution of segmental chromosomal alterations in neuroblastoma.

Peripheral neck nerve tumor: A 73-case study and literature review.

Boumaza K, Michel G, Salaud C, Bossard C, Espitalier F, Malard O
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Nov;136(6):455-460. Epub 2019 Sep 16 doi: 10.1016/j.anorl.2019.09.005. PMID: 31537489

Retinoblastoma.

Melamud A, Palekar R, Singh A
Am Fam Physician 2006 Mar 15;73(6):1039-44. PMID: 16570739

See all (35)